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2026 Vol.30, Issue 2 Preview Page

Clinical or Case Report

Clinical Application of a Porcine-Derived Collagen Matrix: A Case Series
Woo-Taek Song1
,
Ji-Hun Park1
,
Hyun-Jung Oh2
,
Bo-Ah Lee3
,
Young-Taek Kim4*
1Resident, Department of Periodontology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
2Clinical Fellow, Department of Periodontology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
3Clinical Associate Professor, Department of Periodontology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
4Chief of the Department of Dentistry, Department of Periodontology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
*Corresponding Author
30 June 2026. pp. 123-130
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Abstract

Restoration of soft tissue defects is essential for periodontal and implant surgeries. Although autologous grafts remain the gold standard, they increase patient morbidity owing to donor site harvesting. This retrospective case series evaluated the porcine-derived collagen matrix as a less invasive alternative across three indications: vestibuloplasty, soft tissue augmentation, and alveolar ridge preservation (ARP). The xenogeneic matrix showed biocompatibility, favorable initial healing, and rapid epithelialization. The elimination of donor site surgery reduced patient morbidity. The matrix was integrated without notable complications, providing acceptable esthetic and functional contours for both open and closed healing. However, physical limitations including postoperative absorption, decreased tensile strength upon hydration, and rapid degradation were observed as a biomechanical trade-off. In conclusion, this matrix serves as a clinically feasible substitute for autogenous grafts, minimizing discomfort while achieving favorable outcomes.

Keywords
Alveolar ridge augmentation
Case reports
Dental implants
Tissue scaffolds
Vestibuloplasty
References
1

Chambrone L, Botelho J, Machado V, Mascarenhas P, Mendes JJ, Avila-Ortiz G. Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? A systematic review and network meta-analysis. J Periodontol 2022;93:1336-52.

10.1002/JPER.22-0167
2

Cairo F, Nieri M, Pagliaro U. Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review. J Clin Periodontol 2014;41:S44-62.

10.1111/jcpe.12182
3

Zuhr O, Baumer D, Hurzeler M. The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution. J Clin Periodontol 2014;41:S123-42.

10.1111/jcpe.12185
4

Wessel JR, Tatakis DN. Patient outcomes following subepithelial connective tissue graft and free gingival graft procedures. J Periodontol 2008;79:425-30.

10.1902/jop.2008.070325
5

Zucchelli G, Mele M, Stefanini M, Mazzotti C, Marzadori M, Montebugnoli L, et al. Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative randomized-controlled clinical trial. J Clin Periodontol 2010;37:728-38.

10.1111/j.1600-051X.2010.01550.x
6

Thoma DS, Zeltner M, Hilbe M, Hammerle CH, Husler J, Jung RE. Randomized controlled clinical study evaluating effectiveness and safety of a volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation at implant sites. J Clin Periodontol 2016;43:874-85.

10.1111/jcpe.12588
7

Pabst A, Kammerer PW. Collagen matrices: opportunities and perspectives in oral hard and soft tissue regeneration. Quintessence Int 2020;51:318-27.

10.3290/j.qi.a4414932128527
8

Cairo F, Barbato L, Tonelli P, Batalocco G, Pagavino G, Nieri M. Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial. J Clin Periodontol 2017;44:769-76.

10.1111/jcpe.12750
9

Lorenzo R, Garcia V, Orsini M, Martin C, Sanz M. Clinical efficacy of a xenogeneic collagen matrix in augmenting keratinized mucosa around implants: a randomized controlled prospective clinical trial. Clin Oral Implants Res 2012;23:316-24.

10.1111/j.1600-0501.2011.02260.x
10

Furhauser R, Florescu D, Benesch T, Haas R, Mailath G, Watzek G. Evaluation of soft tissue around single-tooth implant crowns: the pink esthetic score. Clin Oral Implants Res 2005;16:639-44.

10.1111/j.1600-0501.2005.01193.x
11

Thoma DS, Sancho-Puchades M, Ettlin DA, Hammerle CH, Jung RE. Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds - a randomized study in humans. J Clin Periodontol 2012;39:157-65.

10.1111/j.1600-051X.2011.01823.x
12

Caballe-Serrano J, Zhang S, Ferrantino L, Simion M, Chappuis V, Bosshardt DD. Tissue Response to a Porous Collagen Matrix Used for Soft Tissue Augmentation. Materials (Basel) 2019;12:3721.

10.3390/ma1222372131718004PMC6888327
13

Caballe-Serrano J, Zhang S, Sculean A, Staehli A, Bosshardt DD. Tissue Integration and Degradation of a Porous Collagen-Based Scaffold Used for Soft Tissue Augmentation. Materials (Basel) 2020;13:2420.

10.3390/ma1310242032466244PMC7287763
Information
  • Publisher :The Korean Academy of Oral & Maxillofacial Implantology
  • Publisher(Ko) :대한구강악안면임플란트학회
  • Journal Title :Journal of implantology and applied sciences
  • Journal Title(Ko) :대한구강악안면임플란트학회지
  • Volume : 30
  • No :2
  • Pages :123-130
  • Received Date : 2026-06-01
  • Revised Date : 2026-06-24
  • Accepted Date : 2026-06-28
  • DOI :https://doi.org/10.32542/implantology.2026010
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