Journal of implantology and applied sciences ISSN:2765-7833(Print) 2765-7841(Online) 대한구강악안면임플란트학회지

For the reconstruction of skeletal defects, autogenous bone graft has been the method of choice. Autogenous bone graft, however, has disadvantage of unpredictable longterm resorption and added morbidity to the patient from the harvesting of bone. Because of these problems, synthetic inorganic ceramic biomaterial, Hydroxyapatite has been developed and made available for craniofacial reconstructive procedures. Hydroxyapatite is biocompatible, and does not stimulate a foreign body reaction, and demonstrates osseous union with bone ingrowth, osteoconduction, and has not been reported to resorb. The purpose of this study is to make bone regeneration: A bone and hydroxyapatite mixture which is able to generate new bone formation by a number of mechanisms such as osteogenesis, osteoinduction and osteoconduction, and is not resorbed by the characteristics of unresorbable hydroxyapatite. If hydroxyapatite itself would play the roleas the matrix that prevents bone resorption, it is deemed unnecessary to mix the same amount of hydroxy apatite particles and bone ones. Therefore varying ratios of 3:7, 5:5, and 7:3 were used to findout the respective amount of bone regeneration from which the most appropriate mixing ratio was to be identified. The results were as follows, 1. In the group which 5:5 ratio of bone and hydroxyapatite particle was used, the greatest number of the osteoblastic cells were observed. 2. The least amount of the osteoblasts were observed in the group which the ratio of hydroxyapatite was high. 3. The greatest number of the osteoclasts were observed in the group which the ratio of bone particle was high. 4. In the group which the bone defect was left untreated, we showed the least amount oh new bone formation. The combination of bone and hydroxyapatite particle can improve the unpredictable resorbability of the bone and add bone induction ability to the hydroxyapatite, so it may provide an excellent alternative to autogenous bone graft. The results of this study suggest that hydroxyapatite particles mixed was bone particles in ratio of 1:1 may be successfully used as a bone extender for reconstructive surgery.