Recombinant Human Bone Morphogenetic Protein-2 Loaded Acellular Dermal Matrix in Horizontal Ridge Augmentation: Two Cases

Hyo-Eun Pak; Jeong-Rae Seo; Hye-Jun Seo; Jang-Ho Son

doi:10.32542/implantology.2025012

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2025 Vol.29, Issue 2 Preview Page

Clinical or Case Report

Recombinant Human Bone Morphogenetic Protein-2 Loaded Acellular Dermal Matrix in Horizontal Ridge Augmentation: Two Cases

30 June 2025. pp. 115-122

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Abstract

Horizontal ridge deficiency in the posterior mandible often necessitates augmentation to achieve optimal implant placement and ensure long-term functional success. Although recombinant human bone morphogenetic protein-2 (rhBMP-2) and acellular dermal matrix (ADM) have individually been explored for bone regeneration, their combined clinical use—especially under functional loading—remains limited. This report presents two clinical cases involving horizontal ridge augmentation using rhBMP-2-loaded ADM without the use of additional grafting material. Radiographic evaluations at 5–6 months postoperatively confirmed horizontal bone gains of 1.5 mm and 1.7 mm, respectively. The newly formed bone was continuous with the adjacent native bone and fully covered the previously exposed implant threads. No postoperative complications, including peri-implantitis or peri-implant mucositis, were observed during the 13- and 10-month follow-up periods.

Keywords

Acellular dermal matrix

Alveolar bone loss

Dental implants

Tissue scaffolds

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